Nyons is a commune in the Drôme department in southeastern France.

Nyons was settled in the 6th century BC as Nyrax by a Gallic tribe, probably the Segusiavi or the Sequani. Hecataeus of Miletus mentioned Nyrax around 500 BC when writing about the Celts. It is situated next to the river Aigues or Eygues, which is crossed by an ancient bridge.